Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV type 1 transmission and AIDS disease progression

Article Abstract:

The genomic DNAs from participants enrolled in five United States-based natural-history cohorts with acquired immunodeficiency syndrome (AIDS) are genotyped for 21 single nucleotide polymorphisms (SNPs) in a 47-kb interval on chromosome 17q12 containing the genes CCL3, CCL4, and CCL18. The findings reiterate the importance of chemokine gene variation in HIV-1/AIDS pathogenesis and emphasize that localized linkage disequilibrium makes the identification of casual mutations difficult.

California, Diagnosis, Prevention, Development and progression, HIV infection, HIV infections, Disease transmission, Chemokines

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Gene-expression variation within and among human populations

Article Abstract:

The patterns of natural gene-expression variation are characterized in people of European and African ancestry. The results have specified insights into how human population structure manifests itself in gene-expression levels and will help guide the search for regulatory quantitative trait loci.

Human population genetics, Quantitative trait loci, Report

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A fast method for computing high-significance disease association in large population-based studies

Article Abstract:

A faster algorithm for accurately calculating low permutation (P) test values in case-control association studies is presented. It shows that this method significantly increases the problem-size range for which accurate, meaningful association results are attainable.

Methods, Analysis, Usage, Genetic research, Permutations, Classification of sciences, Scientific classification

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