High-resolution model of the microtubule
Article Abstract:
A study was conducted to analyze a high-resolution framework of the microtubule. The model supports the docking of the crystal structure of tubulin into a 20 Angstrom map of the microtubule. A nucleotide-sensitive helix associates with a loop during lateral contacts to promote the binding site of taxol in beta-tubulin. Results indicated that the conformation of protofilament is conserved for polymers with no changes in the structure of tubulin or in the longitudinal contacts between subunits.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Costal2, a novel kinesin-related protein in the hedgehog signaling pathway
Article Abstract:
A study was conducted of the Hedgehog (HH) signalling proteins as well as the relationship between costal2 (COS2) and cubitus interruptus (CI). The findings indicate that COS2 encodes a kinesin-related protein the accumulates preferentially in cells that can respond to HH. Furthermore, the association of CI with COS2 in a large protein complex was observed, which suggests that COS2 directly controls CI activity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain
- Abstracts: TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
- Abstracts: TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. part 2 Maternal IL-11R-alpha function is required for normal decidua and fetoplacental development in mice
- Abstracts: Diversity of microorganisms within rock varnish in the Whipple Mountains, California. Microbial community diversity associated with carbon and nitrogen cycling in permeable shelf sediments
- Abstracts: Vaccinia virus encodes a soluble Type 1 interferon receptor of novel structure and broad species specificity. Virus entry: Open sesame