TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Article Abstract:
TGF-beta-activated kinase 1 (TAK1), is estimated to be a key modulator of the inducible transcription factors NF-kappa B and AP-1 and regulates the genes that mediate inflammation. It was not revealed that which member of TAK1 complex is essential for signaling TAK1 or adapter proteins TAB2, but studies suggested that Tak1 acts as an upstream activating kinase for IKKbeta and JNK, with a specific role of it in inflammatory signaling pathways.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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Identification of scaramanga gene implicates Neuregulin3 in mammary gland specification
Article Abstract:
Study is conducted in which positional cloning is used to narrow the interval containing scaramanga (sac) to a 75.6-kb interval containing the distal part of the Neuregulin3 (Nrg3) gene. It is revealed that a Neuregulin signaling pathway is involved in specification of mammary gland morphogenesis.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
User Contributions:
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