Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks
Article Abstract:
The mechanisms of Crb2 recruitment to DNA double-strand breaks (DSBs) is explored by analyzing the phenotypes of fission yeast mutants defective in histone modifications and examining Crb2 relocalization in these mutants using live-cell microscopy and chromatin immuniprecipitation (ChIP). It is proposed that such dual recruitment mechanisms may be a common feature of DNA damage checkpoint mediators.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C
Article Abstract:
A demonstration shows the manner in which chromatin assembly factor Asf1 also affects DNA replication. The histone chaperone protein Asf1 maintains a subset of replication elongation factors at stalled replication forks and directly interacts with the replication machinery.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication
Article Abstract:
The physical association and functional cooperation between two epigenetic factors, DNMT1 and G9a, during DNA replication is described. The direct cooperation between DNMT1 and G9a has provided a mechanism of coordinated DNA and H3K9 methylation during cell division.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
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