Distinctions between c-Rel and other NF-kB proteins in immunity and disease
Article Abstract:
A proto-oncogene c-Rel, previously identified as a cellular counterpart of the v-Rel oncogene, belongs to the NF-KB/Rel factor family that share common DNA recognition and similar pathways. The study of c-Rel knockout mice in several disease model will be discussed for revealing an important role in response to allergens, auto-antigens, allo-antigens and pathogenic infection.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2003
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Repair of exocyclic DNA adducts: rings of complexity
Article Abstract:
Exocyclic DNA adducts are mutagenic lesions that can be formed by both exogenous and endogenous mutagens/carcinogens. It is also apparent that more information is needed for better understanding of the biological and structural implications of exocyclic adducts and their repair.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2004
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The many colours of chromodomains
Article Abstract:
The information gained from the functional and structural studies of chromodomains with a bioinformatic classification of their structure is put forth. The results of the study show an unexpected diversity of interaction targets, including DNA, RNA and histones.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2004
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- Abstracts: Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cyclin E ablation in the mouse
- Abstracts: Prions in Saccharomyces and Podospora spp.: protein-based inheritance. Prions: proteins as genes and infectious entities
- Abstracts: Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
- Abstracts: Relationship between gyrA mutations and quinolone resistance in Flavobacterium psychrophilum isolates
- Abstracts: Reconstitution of the myxothiazol biosynthetic gene cluster by Red/ET recombination and heterologous expression in Myxococcus xanthus