Human pedigree-based quantitative-trait-locus mapping: localization of two genes influencing HDL-cholesterol metabolism
Article Abstract:
Genes located on chromosome 8 and chromosome 15 appear to influence HLD-cholesterol metabolism., according to results of a full genomic scan. Multivariate analyses indicate that the locus on chromosome 8 affects unesterified cholesterol levels, while the locus on chromosome 15 affects concentration of HDL-cholesterol as well as how cholesterol is distributed among different particle sizes of HDL. Data were derived from Mexican American families in the San Antonio Family Heart Study.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans
Article Abstract:
Studies support the location of type 2 diabetes susceptibility in Mexican Americans on chromosome 10q. Using a variance-components process to perform multipoint linkage analyses on 440 Mexican American subjects, researchers found a susceptibility locus near the D10S587 marker that not only influences type 2 diabetes but age at onset as well.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Quantitative trait loci for thermotolerance phenotypes in Drosophila melanogaster. Progress and prospects in mapping recent selection in the genome
- Abstracts: Docosahexaenoic acid, the aquatic diet, and hominin encephalization: Difficulties in establishing evolutionary links
- Abstracts: Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration
- Abstracts: New rapid and simple methods for detection of bacteria and determination of their antibiotic susceptibility by using phage mutants
- Abstracts: Singing in the bird brain. Making conservation make sense