Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain
Article Abstract:
Specialized cells acting as pacemakers generate the rhythmic, spontaneous firing of action potentials, which can control muscle activity and certain autonomic functions. These cells are important on the electrical activity of the heart and brain. Cardiac arrhythmias and various neurological diseases can be attributed to the abnormalities in the pacemaker activity which is generated by a hyperpolarization-activated channel that is permeable to sodium and potassium and is regulated by cyclic nucleotides.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons
Article Abstract:
The influence of HCN1 channels on CA1 pyramidal cell physiology, synaptic integration and induction of LTP at inputs to CA1 pyramidal cells, as well as hippocampal network activity, and hippocampal-dependent forms of learning and memory is examined. It is suggested that HCN1 channels constrain learning and memory by regulating dentritic integration of distal synaptic inputs to pyramidal cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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