Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity

Article Abstract:

Attention-deficit hyperactivity disorder (ADHD) in children is discussed as it relates to association/linkage of the dopamine transporter gene and to study of a sample made up of 122 families with 122 children who had been referred to clinics for behavioral and learning problems, some of which were ADHD. Heterogeneity was found, based on severity and diagnostic subtype, with relation of DAT1 to ADHD increasing monotonically, from low to medium to high levels of severity of symptoms, but the study has some limitations which should be considered.

United States, Psychological aspects, Standards, Planning, Behavior disorders in children, Childhood mental disorders, Attention-deficit hyperactivity disorder, Attention deficit hyperactivity disorder, Dopamine, Psychiatric research, Genetic research, Experimental design, Research design, Twins, Medical statistics, Linkage (Genetics)

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Localization of a gene for familial patella aplasia-hypoplasia (PTLAH) to chromosome 17q21-22

Article Abstract:

Localization of a gene for familial patella aplasia-hypoplasia (PTLAH), a rare genetic defect characterized by genetic absence of the patella or marked reduction of it, is discussed. The gene localized to chromosome 17q21-22 after PTLAH was isolated in an extended Venezuelan family and a genomewide scan was carried out.

Italy, Venezuela, Patella

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