Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase

Article Abstract:

The role of nitric oxide synthase (NOS) in the long-term potentiation (LTP) of CA1 region of hippocampal stratum radiatum was analyzed in mice exhibiting neuronal NOS (nNOS-) mutations. The nNOS- mutant mice exhibited normal LTP of CA1 stratum radiatum. The normal development of the neuronal cells, dendritic and synaptic density of the hippocampus in the mutant mice was not altered by the absence of nNOS-. Furthermore, the mutants also exhibited normal long-term depression and paired-pulse facilitation.

Mice, Mice (Rodents), Brain

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Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons

Article Abstract:

The role of nitric oxide (NO) in the long-term potentiation (LTP) of the CA1 region of the hippocampus was analyzed in cultured hippocampal neurons. LTP was inhibited by the addition of oxymyoglobin (MbO2) in cultured hippocampal cells but the protein did not alter the baseline excitatory postsynaptic current (EPSC) . However, LTP was induced by the addition of NO in the cultured neurons which also increased the frequency miniatures EPSC.

Neural transmission, Synaptic transmission, Neurotransmitters

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