Inherited predisposition to thrombosis
Article Abstract:
Inherited predisposition to thrombosis is a result of combinations of mutations in two or more genes coding for proteins involved in blood clotting. Although a number of genes have been identified with the prothrombotic condition, the nature of gene interactions to produce clinical symptoms are still unclear. The current problems and strategies for genetic analysis of inherited thrombosis are reviewed using a single example, protein kinase C deficiency.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Tumor suppressing pathways
Article Abstract:
Tumor suppressor genes play an important role in colon carcinogenesis. These genes helped identify intermediates in the progression pathway called the adenomatous polyp. Observations concerning the frequent loss of heterozygosity of DNA marker loci on chromosome 18q in colon tumors have also been associated with the genes. Moreover, tumor repressor genes function as an intermediate in the discrimination between initiating events and progression events.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Self-promotion? Intimate connections between APC and prostaglandin H synthase-2
Article Abstract:
Evidence suggests that adenoidal pharyngeal conjunctival (APC) virus loss is connected to increased prostaglandin H synthase-2 (COX-2) transcription. Research shows that COX-2 reaction products contribute to tumorigenesis. Data also reveal that COX-2 expression occurs early in the APC pathway of colon neoplasia, indicating the efficacy of drugs inhibiting COX-2 in the chemoprevention of colon cancer.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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- Abstracts: A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73. Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites
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