Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog-only pathway

Article Abstract:

Crossover recombination between homologous nonsister chromatids has significant mechanical and evolutionary roles during meiosis. Most meiotic interhomolog recombination seems to initiate via DNA double strand breaks (DSB) in yeast. The functional requirements for forming ISJMs and IHJMs have been analyzed to investigate the interhomolog bias of meiotic recombination. It is indicated that meiotic recombination shows an interhomolog bias due to the positive action of meiosis-specific functions to promote a differentiated interhomolog-only recombination process.

Observations, Molecules

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Tn10 transposition via a DNA hairpin intermediate

Article Abstract:

A study was performed to analyze the mechanisms of nontransferred strand cleavage during Tn10 transposition. DNA transposition is a type of genetic recombination wherein genetic elements such as transposons transfer from site to site within and between genomes. It was hypothesized that excision of the double transferred strand occurred through a three-step mechanism involving the generation of a hairpin intermediate by transesterification. Results revealed the formation of the DNA hairpin intermediate at Tn10 ends during the transposition excision reaction.

Translocation (Genetics), Transposons

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Identification of double Holliday junctions as intermediates in meiotic recombination

Article Abstract:

Double Holliday junctions are the joint molecules (JMs) that form during meiotic recombination. The JMs occur due to double-stranded breaks in the chromosomes. The JMs resolve into crossover and noncrossover DNA duplexes on treatment with Holliday junctions-resolving endonucleases. The junctions persist till the end of pachytene and then disappear as the parental and recombinant chromosomes separate. Mismatch base correction of the chromosomes occurs during junction formation and resolution.

Meiosis

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