Biased gene conversion, copy number, and apparent mutation rate differences within chloroplast and bacterial genomes

Article Abstract:

A theoretical analysis was conducted to determine the role of gene conversion in the differences between the synonymous substitution rates of organelle and bacterial genes differing only in copy number. The analysis showed that biased gene conversion can control the fixation or loss of a mutant allele. The number of gene copies influences the conversion dynamics and hence, the mutation rate. Higher copy numbers can result in either higher or lower mutation rates, depending on the lethality or viability of the unrepaired mutants.

Analysis, Genetic aspects, Chloroplasts, Mutation (Biology), Mutation

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How often do duplicated genes evolve new functions?

Article Abstract:

Amodel study helps investigate the evolution of new functions in recently duplicated genes. The recently duplicated gene can fix an advantageous allele giving it a slightly different, and selectable, function thereby facilitating the evolution of a new function. On the other hand the recently developed gene can fix a null allele, forming a pseudogene. The model study investigates the probabilities of these two events.

Research, Models, Evolution (Biology), Evolution, Genetics

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Similar abstracts:

• Abstracts: Intracellular selection, conversion bias, and the expected substitution rate of organelle genes. Simulation study of a multigene family, with special reference to the evolution of compensatory advantageous mutations

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