Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli
Article Abstract:
Several strategies to reengineer central metabolism in Escherichia coli were investigated for synthesis of flavanones. The reengineering was targeted towards the multisubunit complex of acetyl-CoA carboxylase (ACC)-biotin ligase (BirA) and enzymes in acetate assimilation pathways in Escherichia coli.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2007
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Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli
Article Abstract:
A series of artificial isoflavone synthases are designed that have allowed the production of plant estrogen pharmaceuticals by Escherichia coli. This biological device is an excellent strategy for using the laboratory bacteria to manufacture high-value plant P450 products.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2007
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