Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock

Article Abstract:

The MAP kinase cascade and its possible role in resetting the mammalian circadian clock are discussed in this research communication. The suprachiasmatic nucleus (SCN) is the primary timing center in mammals, but peripheral/ immortalized cells have a circadian clock as well. Induction of the circadian oscillation of gene expression is started by TPA treatment of NIH-3T3 fibroblasts. NIH-3T3 is inhibited by a MEK inhibitor. Prolonged activation of the MAPK cascade is sufficient to bring on circadian gene expression.

Japan, Biochemistry, Physiological aspects, Genetic aspects, Circadian rhythms, Genetic regulation, Cytochemistry, Protein kinases, Mammals

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Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage

Article Abstract:

Pds1 and Esp1 control of mitotic and anaphase exit after DNA damage and in normal cells are discussed. Pds1 has been found to be an inhibitor of anaphase and also to block cyclin destruction and mitotic exit. Inhibition of cyclin destruction by Pds1 may help order late mitosis by making sure mitotic exit waits until anaphase starts. After DNA damage, stabilization of Pds1 gives a way to delay anaphase and mitotic exit while DNA repair goes on.

United States, Statistical Data Included, DNA repair, DNA damage, Physiological regulation, Cellular control mechanisms, Cell regulation, Biological control systems, Mitosis, Sister chromatid exchange, Anaphase

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