Kelch encodes a component of intercellular bridges in Drosophila egg chambers
Article Abstract:
The role of intercellular bridges called ring canals during oocyte maturation in Drosophila was investigated. Oocyte maturation is supported by a cluster of 15 germline-derived nurse cells which contribute cytoplasmic material to the oocyte through ring canals. The study protocol involved the cloning of the kelch gene from a female sterile mutation which affects transport of cytoplasmic material through the ring canals. Two protein products from the kelch mRNA were produced. One of these proteins is conserved and is localized to the ring canal, suggesting that kelch is a ring canal component which regulates the flow of cytoplasm between cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Drosophila ring canal growth requires Src and Tec kinases
Article Abstract:
Ring canals form between sister oocytes during the development of germ cells in Drosophila. An analysis of the formation of the ring canals in two protein kinase Drosophila mutants reveal the particular requirement of ring canal formation for the Src and the Tec kinases. Immunostaining reveals that Src localizes in the nurse cells while Tec localizes in the ring canal. It is postulated that Src is necessary for the localization of Tec in the ring canal.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Germline cysts: communes that work
Article Abstract:
The role of intercellular bridges which are formed during oogenesis or spermatogenesis was investigated. The study protocol involved the examination of the transport of materials through the intercellular bridges called ring canals between oocytes and associated nurse cells during Drosophila oogenesis. The results showed that ring canals have equally important roles in cyst formation and in differentiation during Drosophila oogenesis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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