Lateral and axial signals involved in avian somite patterning: a role for BMP4
Article Abstract:
An early and selective molecular marker for lateral somitic cells in the chick, cSim1, was identified. Genetic analyses showed cSim1 is an avian homolog of the Drosophila single minded (sim) gene. With this marker, it was shown that factors produced by the lateral plate activates cSim1 expression in the lateral somitic cells, which is counteracted by diffusible signals from the neural tube and from the lateral plate mesoderm. It is suggested that the bone morphogenic protein produced by the lateral plate cells directs the specification of the lateral somitic lineage.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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The divergent robo family protein Rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons
Article Abstract:
Commissural axons in vertebrates as well as insects are normally attracted to the nervous system midline, on reaching, which they undergo a switch and become responsive to repellant Slit proteins which propel them to the next level of their path. Genetic as well as in-vitro analysis of show that Rig-1 functions to repress Slit responsiveness similar to commissureless in drosophila but unlike commissureless Rig-1 does not produce its effect by downregulating Robo receptors on precrossing commissural axon membrane.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching
Article Abstract:
The development of single sensory axons in an in vitro collagen assay system was examined to determine molecular regulators of axon branch initiation or extension. Activity of extracts of embryonic spinal cord and of postnatal and adult brain that supports the elongation and formation of extensive branches of the axons was also studied. Results indicate that the amino-terminal fragment of Slit2 protein is the primary regulator of axon collateral formation during the creation or remodeling of neural circuits.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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