Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region

Article Abstract:

Linkage analysis has been carried out on human leukocyte antigen (HLA) markers in familial psoriasis. Sporadic and familial psoriasis have the same risk alleles and it can be seen that substantial parametric linkage information can be had by accounting for linkage disequilibrium. It seems a major susceptibility gene is near HLA-C. Strong disequilibrium effects have provided evidence for a major determinant in the HLA-B/-C region. Evidence for linkage to HLA markers has been limited although psoriasis is strongly associated with certain human leukocyte antigens.

Germany, Genetic aspects, HLA histocompatibility antigens, HLA antigens, Chromosome mapping, Genetic disorders

---

Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene

Article Abstract:

A study to identify the PSORS1 gene, the psoriasis-susceptibility locus in the major histocompatibility complex (MHC) is presented. The results suggest that HLA-Cw6 is the PSORS1 risk allele that confers susceptibility to early-onset psoriasis.

Michigan, Health aspects, Causes of, T cells, Messenger RNA, Haplotypes

---

Family-based association tests for genomewide association scans

Article Abstract:

A computationally efficient approach to test association between single-nucleotide polymorphisms (SNPs) and quantitative phenotypes which could be applied to whole-genome association scans is described.

Algorithms, Phenotype, Phenotypes, Algorithm, Human genome, Single nucleotide polymorphisms, Pedigree analysis, Report

Similar abstracts:

• Abstracts: A reanalysis of the indirect evidence for recombination in human mitochondrial DNA. Direct evidence of recombination in human mitochondrial DNA
• Abstracts: Evaluation of Canine COL4A3 and COL4A4 as Candidates for Familial Renal Disease in the Norwegian Elkhound. RAS Gene Hot-Spot Mutations in Canine Neoplasias
• Abstracts: Randomly amplified polymorphic DNA analysis of clinical and environmental isolates of Vibrio vulnificus and other Vibrio species
• Abstracts: A discordant sibship test for disequilibrium and linkage: no need for parental data. Efficient study designs for test of genetic association using sibship data and unrelated cases and controls

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.