Localized calcium signals in early zebrafish development
Article Abstract:
Phosphoinositide (PI) and calcium (Ca2+) are key to the embryogenesis of early vertebrates. With the hypothesis that the PI pathway and intracellular Ca2+ signals are usually associated, the time and location of such signals during zebrafish embryogenesis is studied. In situ studies show that the PI pathway is activated in the cells of the outer embryonic layer which forms the enveloping layer (EVL) and Ca2+ signals are first seen in the 32- to 128-celled stage. These signals are seen only in the EVL cells till the start of gastrulation and deeper blastomeres do not show any Ca2+ spikes. Synchronization in the Ca2+ signals is also seen in groups of EVL cells.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Developmental changes in the distribution of the endoplasmic reticulum and inositol 1,4,5-trisphosphate receptors and the spatial pattern of Ca2+ release during maturation of hamster oocytes
Article Abstract:
The distribution of the endoplasmic reticulum (ER) and inositol 1,4,5-triphosphate receptors (InsP3Rs) changes significantly during maturation of hamster oocytes. The development changes may contribute to the egg's capacity for normal fertilization. The changes were revealed using confocal microscopy with DiI and electron microscopy for the ER and immunohistochemistry for InsP3Rs. Developmental changes in the ER involve an increase in surface ER masses, dispersion of the ER masses, changes in perinuclear ER, and redistribution of the ER network and InsP3Rs throughout the cytoplasm. Spatial maturation of Ca2+ stores also occurs.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
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