Pole cell migration through the gut wall of the Drosophila embryo: analysis of cell interactions
Article Abstract:
The process by which the pole cells cross the epithelial wall of the posterior midgut primordium in Drosophila embryos has been examined, using laser scanning confocal microscopy on whole-mount Rh-phalloidin-stained embryos and transmission electron microscopy. Results suggest that the pole cells travel through the intercellular spaces of the epithelium as they leave the midgut sac. This process results in substantial deformation of the epithelial cells at the bottom of the posterior midgut primordium, but breaks in the epithelial wall are avoided since the junctional complexes do not completely release.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Native and recombinant DM-GRASP selectively support neurite extension from neurons that express GRASP
Article Abstract:
A study was conducted to analyze the effects of purified GRASP, a new immunoglobulin that has two V-type and three C-type IG domains, on the maturation of the chick nervous system. Responses of different neuronal tissue types to GRASP revealed a higher level of expression in the sensory, sympathetic and ciliary neurons than in tectal, diencephalic and retinal cells. GRASP introduced in sensory neurons during development lose capacity to extend neurites on a GRASP substrate. This supports the assumption that GRASP is expressed in a restrictive manner in the nervous system.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Embigin, a member of the immunoglobulin superfamily expressed in embryonic cells, enhances cell-substratum adhesion
Article Abstract:
A functional analysis of the glycoprotein embigin, which belongs to the immunoglobulin superfamily, was undertaken. Embigin cDNA that is controlled by the beta-actin promoter and the Rous sarcoma virus enhancer was introduced to L cells. The transfectants exhibited enhanced cell-substratum adhesion activity. Moreover, this property was found to be Ca2+-dependent and inhibited by an anti-integrin antiserum and a Gly-Asp peptide, which competitively inhibits integrins. Thus, these findings suggest that embigin participates in integrin-mediated cell-substratum adhesion.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1993
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- Abstracts: Polygenic mutation in Drosophila melanogaster: genetic analysis of selection lines. On models of quantitative genetic variability: a stabilizing selection-balance model
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