Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions

Article Abstract:

Locomotion defects (Loco) interacts and colocalizes with Galphai and, through its GoLoco motif, acts as a guanine nucleotide dissociation inhibitor (GDI) for Galphai. Simultaneous removal of the two Goloco motif proteins results in defects that are essentially indistinguishable from those observed in Gbeta13F or Ggamma1 mutants, suggesting that Loco and Pins act synergistically to release free Gbetagamma in neuroblasts.

Biological Product (except Diagnostic) Manufacturing, Drugs, Guanine, Gene mutations, Gene mutation, Drosophila, G proteins

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Global analysis of alternative splicing differences between humans and chimpanzees

Article Abstract:

Comparative genomics and quantitative microarray profiling are used for the global analysis of alternative splicing differences between humans and chimpanzees. The alternative splicing differences might affect diverse functions including gene expression, signal transduction, cell death, immune defense and susceptibility to diseases.

Research and Development in the Physical, Engineering, and Life Sciences, Genetic Engineering, Chimpanzees, Structure, DNA microarrays, Human genome

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