Looking for the homunculus in Drosophila
Article Abstract:
The complex cellular interactions governing the fate and development of cells are being elucidated by new approaches in molecular biology. Initial research focused on the separation of the programming events for cell determination, and the expressionof this program, referred to as differentiation. These were most clearly illustrated by Hadorn's studies on imaginal discs, which showed that cells werefully determined by the third-instar larval stage. However, recent research indicates that earlier stages in embryogenesis and oogenesis, involving coordinated interactions of maternal and zygotic genes, have a key role in establishing the eventual fate of cells.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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A genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster
Article Abstract:
The Notch gene is a well-characterized geneinvolved in the determination of cell fate of Drosophila. It is only one of a number of interacting genes during cell development. Another gene, designated deltex, was determined to act with Notch in cell fate programming. Notch and deltex mutants are phenotypically similar, but double mutant analysis showed that the genes code for different functions. The two genes function together inmany developing tissues. Therefore, deltex and Notch are involved in one or more developmental pathways in cell determination.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster
Article Abstract:
Genetic studies indicate the presence of three classes of mutations in the cubitus interruptus (ci) gene, which modulate the regulation of ci expression in Drosophila melanogaster. Elimination of ci expression by two classes of embryonic mutations occurs at different stages of embryogenesis. This elimination exhibits a correlation with the elimination of wingless expression. Normal Drosophila development is influenced by the regulation of both the ci mRNA and proteins.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1995
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