Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
Article Abstract:
A series of Wnt target molecules in an in vivo setting is considered and a series of new candidate targets within the same setting are identified. Using a novel inducible Ahcre allele, it is shown that loss of Apc acutely activates Wnt signaling through accumulation of beta-catenin.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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Wnt signaling in the intestinal epithelium: From endoderm to cancer
Article Abstract:
The understanding of the physiological role of Wnt signaling in intestinal biology is emphasized. Existing evidence validates the Wnt cascade, in particular the beta-catenin and Tcf4complex, as a target for therapeutic strategies in the treatment of colorectal cancer.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
Article Abstract:
Research has been conducted on Wnt signals in intestinal crypts. The authors have investigated these signals via the use of generated transgenic mice which express ectopically secreted Wnt inhibitor.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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