Macromolecular complexes that unwind nucleic acids
Article Abstract:
The integration of helicases with the macromolecular machines of gene expression is discussed as illustrated by macromolecular complexes, which direct and control DNA replication and DNA-dependent RNA transcription. Research indicates that the unwinding of double-stranded nucleic acids by these complexes can be regulated by small changes in the interactions of their functional components.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2003
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Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins
Article Abstract:
This review article discusses the molecular mechanisms and recently discovered initiator proteins that regulate the initiation step of DNA replication in eukaryotic cells. Research suggests that all of the components of initiator macromolecular complex are assembled in an orderly manner and consists of pre-replication, pre-initiation, and post-replication complexes.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2003
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Epigenomic replication: linking epigenetics to DNA replication
Article Abstract:
This review discusses the link between DNA replication and epigenetic inheritance with respect to the participation of chromatin proteins and replication machinery components. These genomic and epigenetic events occuring during S-phase determine either changing or maintaining existing epigentic states.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2003
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