STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo
Article Abstract:
The developmental switching of the mutually exclusive alternative splicing of the let-2 gene of Caenorhabditis elegans from exon 9 form in embryos to the exon 10 form in adults is studied. The usage of let-2 mutually exclusive exons through differential expression of green and red fluorescent protein identified the alternative splicing defective-2 gene, encoding a novel member of evolutionarily conserved STAR family of RNA-binding proteins.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2008
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Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene
Article Abstract:
A comparative genomics approach was undertaken to identify the proteins involved in ciliary and basal body biogenesis and function. A novel gene for Bardet-Biedl syndrome (BBS5) was identified with the study of human ciliation disorders.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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- Abstracts: Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport
- Abstracts: Post-transcriptional small RNA pathways in plants: Mechanisms and regulations. Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA