Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation

Article Abstract:

Genetic inactivation of AST/SF2 resulted in cell cycle arrest in G2 phase and morphological changes associated with apoptosis and blocks DNA fragmentation. Studies reveal association between ASF/SF2, cell cycle progression, and apoptotic cell death, and illustrate the physiological significance of the regulation of ICAD pre-MRNA alternative spilling in the process of apoptotic DNA fragmentation.

Cell cycle, Morphogenesis, Apoptosis

---

The search for alternative splicing regulators: new approaches offer a path to a splicing code

Article Abstract:

A study is made to understand the changes in the alternative splicing (AS) patterns in terms of changes in expression and regulation of factors that regulate AS across cell types. It is suggested that a combination of approaches would be useful in explaining the tissue specificity of a large number of AS events.

Research and Development in the Physical, Engineering, and Life Sciences, Genetic Engineering, Genetic regulation, Chemical evolution (Origin of life), Chemical evolution

---

Sumolyation regulates multiple aspects of mammalian poly(A) polymerase function

Article Abstract:

The article explains the role and importance of the small ubiquitin-like modifier (SUMO) in regulating the poly(A) polymerase (PAP) function in mammals. The in vitro sumoylation is found to highly inhibit the process of purifying PAP by regulating its different aspects.

Analysis, Physiological aspects, Genetic aspects, Eukaryotes, Polymerase chain reaction, Ubiquitin-proteasome system

Similar abstracts:

• Abstracts: Power analysis for real-time PCR quantification of genes in activated sludge and analysis of the variability introduced by DNA extraction
• Abstracts: Relative ability of orally administered Lactobacillus murinus to predominate and persist in the porcine gastrointestinal tract
• Abstracts: Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. N-terminal polyubiquitination and degradation of the Arf tumor suppressor
• Abstracts: A CBP integrator complex mediates translational activation and AP-1 inhibition by nuclear receptors. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
• Abstracts: Tcf3 governs stem cell features and represses cell fate determination in skin. Socializing with the neighbors: Stem cells and their niche

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.