MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos
Article Abstract:
The anterior blastomere of C. elegans produces muscles and hypodermal cells during embryogenesis due to mutations in the mex-3 gene. The mex-3 gene alters AB activity during embryogenesis by encoding a probable ribonucleic acid(RNA)-binding protein which affects the expression of RNAs in the embryo. However, the mutagenic activity of mex-3 is not similar to the actions of met-1 and, therefore, indicating that mex-3 mutation does not involve the misexpression of SKN-1 in AB blastomere.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm
Article Abstract:
EMS is a Caenorhabditis elegans four-cell stage blastomere that produces a polarizing signal that promotes endoderm production. A study on the genes mom-1 through mom-5 revealed that 16 mutations are needed for EMS to generate endoderm. Results also reveal that mom-1, mom-2 and mom-3 are vital to the P2 signaling cell and mom-4 is is needed in EMS. Furthermore, blastomere cytoskeletal polarity was found to be affected by Wnt signaling during the early stages of the embryo.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell
Article Abstract:
Wnt pathway components in the early Caenorhabditis elegans embryo are discussed. These components orient a mitotic spindle without requiring gene transcription in the responding cell. A C. elegans GSK-3 beta gene that may act as a branchpoint for endoderm specification and spindle orientation has been identified and a subset of the C. elegans Wnt pathway genes necessary for endoderm specification are necessary for proper orientation of the EMS, blastomere, spindle
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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