Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes

Article Abstract:

Mechanisms by which translational silencing of certain mRNAs in growing oocytes take place and awakening during meiotic maturation are not well understood. Binding of a protein of about 80-kD to a UA-rich element in the 3' UTR of tissue-type plasminogen activator mRNA silences the mRNA in primary oocytes. The particular RNA involved is a mouse oocyte mRNA translated during meiotic maturation. Masking/unmasking and regulated polyadenylation are cooperative in translation control of the dormant mRNA in mouse oocytes.

Mice, Mice (Rodents), Gene expression, Messenger RNA, Genetic translation, Translation (Genetics), Oocytes, Oocyte donation

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A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction

Article Abstract:

Results show that depletion of the cohesion protein REC-8 of Caenorhabditis elegans, between metaphase I and II, gives rise to univalent and split chromosomes at diakinesis. Data further indicate that double stranded DNA breaks also result due to the REC-8 depletion and they can be repaired by restoring REC-8 expression.

Austria, Genetic recombination, Caenorhabditis elegans, Chromosome abnormalities

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Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes

Article Abstract:

Research has been conducted on the meiotic cells. Experiments reveal the absence of the universal mitotic inhibitor in Xenopus oocytes.

Japan, Physiological aspects, Cell cycle, Xenopus, Genetic research

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