Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-Beta signaling
Article Abstract:
A new DNA binding motif was revealed when the crystal structure of a Smad3 MH1 domain bound to a DNA sequence was examined using a 2.8 armstrong resolution X-ray. An 11-residue Beta hairpin embedded in the DNA provides the base-specific DNA recognition in the crystals. A surface loop region, where tumorigenic map, was found to be a functional surface that is important for Smad activity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Determinants of specificity in TGF-beta signal transduction
Article Abstract:
Signal transduction on the part of the TFG-beta family has been studied. Discrete structural elements that determine selective interactions between receptors and Smads in the TGF-beta and BMP pathways have been identified. Others between Smads and transcription factors have also been identified. The determinants keep TGF-beta and BMP pathways separated from one another.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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