Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family
Article Abstract:
Spo11, a member of a widely conserved protein family, is found to be the catalytic subunit of the meiotic recombination in Saccharomyces cerevisiae as initiated by double-strand breaks (DSB). Spo11 is identified as one of many proteins required for DSB formation. It is the first time that a biochemical function for any of the gene products involved in DSB formation is identified. It was also found that the S. pombe homolog rec12p is required for meiotic recombination. These results provide evidence that the mechanism of meiotic recombination initiation is highly conserved.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Crossover homeostasis in yeast meiosis
Article Abstract:
Homologous recombination is examined when breaks are reduced in yeast spo11 hypomorphs to understand the decision by which some breaks give crossovers while others follow a mostly noncrossover pathway(s). A previously unexpected expression of crossover control is defined whereby the crossover/noncrossover ratio can change to maintain crossovers and the theory that an obligate crossover is a genetically programmed event tied to crossover interference is supported by the results.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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