RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination
Article Abstract:
Two major pathways for repairing double-strand breaks (DSBs), homologous recombination and non-homologous end joining (NHEJ) are assumed to operate in different stages of the cell cycle. Studies were conducted to confirm this assumption and it is seen that mutations that form unstable RAG post-cleavage complexes permit DNA ends to participate in both homologous recombination as well as the error-prone alternative NHEJ pathway.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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A transforming principle
Article Abstract:
Several experiments in yeast reveal that protein can also transform cells in the same formal sense that is so convincing for DNA. The identification of a protein as the key molecule in [PSI+] inheritance set the stage for this transformation experiment as the yeast prion [PSI+] results from self propagating aggregation of Sup35p, a protein required for efficient termination of translation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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