Metabolism of inositol 1,4,5-triphosphate in Candida albicans: significance as a precursor of inositol polyphosphates and in signal transduction during the dimorphic transition from yeast cells to germ tubes

Article Abstract:

The metabolism of inositol 1,4,5-triphosphate (Ins(1,4,5)P3) and its role as a precursor of inositol polyphosphates and in signal transduction mechanism in the dimorphic transition of Candida albicans from yeast cells to germ tubes were investigated. Findings revealed that both germ tubes and yeast cells of Candida albicans rapidly phosphorylated inositol triphosphate to inositol polyphosphates. A marked increase in cellular inositol triphosphate was noted during germ tube formation than during yeast-like growth.

Analysis, Enzymes, Inositol phosphates, Transduction, Transduction (Genetics)

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Pleiotropic effects of the opi1 regulatory mutation of yeast: Its effects on growth and on phospholipid and inositol metabolism

Article Abstract:

Membrane biogenesis must be coordinated closely with cell growth and division. The key factors that have an effect on the biosynthesis of the phospholipid precursor inositol have been studied in the yeast Saccharomyces cerevisiae. Overexpression of the INO1 gene and overproduction of inositol was found to vary as a function of growth phase. The predominant phospholipid, phosphatidylcholine showed an inverse profile, and phosphatidylcholine content was lowest in opi1 cells.

Saccharomyces, Phospholipids

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Restoration of inositol prototrophy in the fission yeast Schizosaccharomyces pombe

Article Abstract:

A study of the possible reasons for the absence of Pichia pastoris INO1 gene in Schizosaccharomyces pombe was conducted. The overproduction of intracellular inositol failed to produce a single discernible side effect. An investigation of the natural environment of Sch. pombe, which contains substantial amounts of phytic acid, revealed that fission yeast is capable of utilizing phytic acid under very specific conditions as a source of inositol.

Genetic aspects, Yeast, Yeast (Food product), Phototropism, Phytic acid

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