Molecular chaperones activate the Drosophila ecdysone receptor, an RXR heterodimer
Article Abstract:
Molecular chaperones have been found to activate the Drosophila ecdysone receptor (EcR), which is an RXR heterodimer. Two of the six proteins normally in the chaperone complex and sufficient for the activation of EcR/USP DNA binding activity are needed in vivo for ecdysone receptor activity. EcR is the main target of the chaperone complex. The steroid hormone 20-hydroxyecdysone manages stages of Drosophila development, activating a nuclear receptor heterodimer made up of EcR and USP, the Drosophila RXR receptor. It has been shown that EcR/USP DNA binding activity must have activation by a chaperone heterocomplex similar to that needed for activation of the vertebrate steroid receptors. It was not shown before to be necessary for activation for RXR heterodimers.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Cosuppression of nonhomologous transgenes in Drosophila involves mutually related endogenous sequences
Article Abstract:
Demonstration that two nonhomologous reciprocal fusion genes, white-Alcohol dehydrogenase (w-Adh)(ital) and Adh-w(ital), in Drosophila show cosuppression using the endogenous Adh(ital) sequence as an intermediary is discussed. A nontranscribed segment in the Adh(ital) regulatory region has been found to be one of the sequences necessary for recognition of homology. The silencing interaction is started in early development. Silenced transgenes are associated with the Polycomb group complex of chromatin proteins.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Noncoding RNA genes in dosage compensation and imprinting
Article Abstract:
New findings on dosage compensation and how it is controlled in mice, unexpected parallels in Drosophila and four unusual genes involved in dosage compensation are discussed in this review article. The genes may act through RNA products. The list of RNAs required for protein synthesis has grown to many more than three. Now the RNAs associated with chromatin are to be added. Chromosomal RNAs act in cis near sites of their synthesis, implying a novel RNA localization mechanism.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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