The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development

Article Abstract:

The MAR-binding protein SATB1 is in control in spatial and temporal expression of various genes in T-cell development. SATB1-null mice were generated to find out how SATB1 acts in the T-cell lineage.

Japan, Analysis, Chromatin, T cells

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Cooperative effects of genes controlling the G(sub.2)/M checkpoint

Article Abstract:

Genes controlling the G(sub.2)/M checkpoint and cooperative effects they have are discussed. Results show p21 and 14-3-3(sigma) have complementary roles in the G2/M checkpoint. Human cells deficient in p21 and 14-3-3(sigma) were generated. Study was made of whether the double knockout was more sensitive to DNA damage than either one of the single knockouts. Results of the study contribute to understanding of why genes at the nodal points of growth-arrest pathways, such as p53, are targeted for mutation in cancer cells. Multiple effectors are thought to independently control the checkpoints allowing transition between cell cycle phases, but in mammal cells this has not been shown definitively.

Physiological aspects, DNA damage, Cell cycle, Cancer cells, Mammals

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Vein expression is induced by the EGF receptor pathway to provide a positive feedback loop in patterning the Drosophila embryonic ventral ectoderm

Article Abstract:

Vein expression is induced to be a positive feedback loop in patterning Drosophila embryonic ventral ectoderm by the EGF receptor pathway. Presence of a single EGF receptor in Drosophila is activated by multiple ligands. Two ligands, Spitz and Vein, in the embryonic ventral ectoderm have roles. Vein is intrinsically a weak activating ligand but Spitz is a powerful ligand. Secreted Spitz comes out of the midline and brings on expression of vein in the most ventral cell rows. It induces expression of the ETS domain transcription factor Pointed P1. Where Vein is not present, lateral cell fates are not induced when there are compromised Spitz levels. The positive feedback loop of Vein brings on a strong mechanism for patterning ventral ectoderm.

Drosophila, Ectoderm

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