A proteasome howdunit: the case of the missing signal
Article Abstract:
The question of whether or not ODC and p21(super.cip1) make up a class of proteins that can be degraded by the proteasome in vivo without ubiquitination to help is discussed in this minireview article. Reasons for eukaryotic proteasomes to have evolved such strong preference for ubiquitinated substrates are presented, given that they differ in this respect from the very similar prokaryotic counterparts.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system
Article Abstract:
Ubiquitin-proteasome system (UPS) possibly consists of the recruitment of ubiquitinated proteins to the 26S proteasome. An additional layer of substrate selectivity in UPS may be provided by the recruitment of substrates to the proteasome by the multiubiquitin chain binding proteins (MCBPs).
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
The exosome: a proteasome for RNA?
Article Abstract:
Organization and functions of the exosome are discussed in this review article. In yeast it is a protein complex made up of a core of at least ten proteins, all ten proposed to be active 3'-to-5' exoribonucleases, and is found in the nucleus and cytoplasm. It has an important RNA processing/degradation function in eukaryotic cells and probably has functions not yet known. Evidence indicates that it is conserved in eukaryotes. Differences in structure may exist from species to species.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase
- Abstracts: The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Protein-protein interactions define specificity in signal transduction
- Abstracts: Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro
- Abstracts: Fusarium species from Nepalese rice and production of mycotoxins and gibberellic acid by selected species. Heritability of fumonisin B1 production in Gibberella fujikuroi mating population A
- Abstracts: Inactivation of exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility