Essential role of Max in early embyronic growth and development

Article Abstract:

The role of Max, of the Myc superfamily, in early embyronic growth and development is an essential one recent research has shown. Max acts as obligate dimerization-DNA-binding partner for Myc oncoproteins and Mad transcriptional repressors. A mouse losing Max function has developmental arrest of both embryonic and extra-embryonic tissues in general at early postimplantation at the same time as loss or dilution of maternal Max stores in the expanding embryo in vivo. The same happens in vivo in blastocyst outgrowth.

Carrier proteins, Transport proteins, Embryology, Experimental, Embryological research

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Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

Article Abstract:

Myc-enhanced expression of Cul1 has been found to promote ubiquitin-dependent proteolysis and progress of the cell cycle. The cMyc oncoprotein has an important role in growth and proliferation of normal and neoplastic cells. It seems to regulate functionally diverse gene sets that directly govern cellular mass and progression through critical cell cycle transitions.

Cell cycle, Tumors, Proteolysis, Oncogenes, Ubiquitin

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RANK is essential for osteoclast and lymph node development

Article Abstract:

RANK, a tumor necrosis factor receptor family member, gives critical signals for lymph node and osteoclast development. RANK-deficient mice were generated for the study. The mice had profound osteopetrosis, apparently from a block in osteoclast differentiation. The mice had marked deficiency of spleen B cells.

Proteins, Bone resorption, Cell differentiation, Immunocytochemistry, Cell receptors, Hematopoiesis, Tumor necrosis factor, Lymph nodes, Osteopetrosis

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