A role for neural determination genes in specifying the dorsoventral identity of telecephalic neurons

Article Abstract:

Study results show that Mash1 and Neugenins 1 and 2 (Ngns) have a role in specification of dorsal-ventral neuronal identity as well as acting as neuronal determinants. They link pathways of neurogenesis and regional patterning in the forebrain directly. The replacement of the Ngns by Mash1 in dorsal prgenitors was used to look at the role of the neural detmination genes in neruonal-type specification in the telencephalon.

Usage, Physiological aspects, Mice, mutant strains, Mutant mice, Homeobox genes, Cerebral cortex, Thalamus, Neurogenetics, Cell migration, Prosencephalon, Neural tube

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Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis

Article Abstract:

Pan-neural Prospero has been found to end cell proliferation in Drosophila neurogenesis. Drosophila prospero encodes a vital regulator of transition from mitotically active cells to totally differentiated neurons. Loss of pros bring aberrant expression of various cell-cycle regulating genes and ectopic mitotic activity. Ectopic pros expression on the other hand brings transcriptional suppression of multiple cell-cycle regulatoring genes and early termination of cell division.

Cell cycle, Cell differentiation, Cellular control mechanisms, Cell regulation, Drosophila, Mitosis, Cell division, Cell proliferation

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NEUROGENIN1 and NEUROGENIN2 control two distinct waves of neurogenesis in developing dorsal root ganglia

Article Abstract:

NEUROGENIN1 and NEUROGENIN2 regulate two separate neurogenesis waves, the large-diameter trkC+ and trkB+neurons one and the small-diameter trkA+ neurons one, in developing dorsal root ganglia (DRG). The neurons of these types must have either neurogenein (ngn) 1 or 2 (ital) , neuronal determination genes that encode basic helix-loop-helix (bHLH) transcription factors. Major parallels have been seen in the roles of basic bHLH factors in neurogenesis in the DRG and in myogenesis in the nearby myotome in studies in chicks.

Statistical Data Included, Sensory receptors, Chickens

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