Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
Article Abstract:
Multiple repression domains (RDs) seen in certain corepressors that mediate transcriptional repression have been shown to be nonredundant. One RD conserved in N-coR and SMRT represses transcription by interacting directly with class II HDAC4/5. Endogenous N-CoR and SMRT associate with HDAC4 in a complex that does not have HDAC1 or mSin3A. The first instance of one corepressor using definite domains to engage multiple HDAC complexes has been seen. Alternative HDAC complexes may mediate specific repression pathways in leukemic and normal cells.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
Article Abstract:
A core silencing mediator for retinoid and thyroid receptors (SMRT) corepressor complex with TBL1, a WD40-repeat protein linked to deafness, is discussed. The corepressor also contains HDAC3 and the complex comprises transducin beta-like protein 1 (TBL1). The TBL1 gene is mutated in human sensorineural deafness. Isolation of a SMRT-containing complex from HeLa cells has been achieved. SMRT mediates repression by thyroid hormone receptor (TR). It also mediates repression by other nuclear hormone receptors and transcription factors. Loss-of-function TR(beta) mutations bring on deafness in humans and mice. HDAC3 is a histone deacetylase that not been thought to interact with SMRT. TBL1 is bridged to HDAC3 through SMRT. It can potentiate repression by TR.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Proteasomal regulation of nuclear receptor corepressor-mediated repression
Article Abstract:
Gene transcription repression is basic to nuclear hormone receptors. Cell-specific repression by nuclear receptors relates to levels of nuclear receptor corepressor (N-CoR) protein, based on recent experimentation. Aimed proteolysis of transcriptional coregulators has been found to be a path for cell-specific regulation of gene transcription.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Leaky Lactococcus cultures that externalize enzymes and antigens independently of culture lysis and secretion and export pathways
- Abstracts: Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Essential role of Max in early embyronic growth and development
- Abstracts: Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin
- Abstracts: Body temperature and resting behavior of Greater Snow Goose goslings in the high Arctic. The thermal regime of eggs during laying and incubation in Greater Snow Geese
- Abstracts: Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invation and angiogenesis