Nef harbors a major determinant of pathogenicity for an AIDs-like disease induced by HIV-1 in transgenic mice
Article Abstract:
Transgenic (Tg) mice expressing the entire coding sequences of HIV-1 in CD4+ T cells were found to develop AIDS-like pathologies. Nef was found to harbor a major disease determinant, and the latency and progression of the disease was strongly linked to levels of Tg expression. There are similarities with human AIDS, indicating that nef may play an important role in human AIDs, independent of its involvement in virus replication.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Hippi is essential for node cilia assembly and Sonic hedgehog signaling
Article Abstract:
The effects of Hippi expression on Sonic hedgehog pathway and huntingtin signaling, using knock out mice studies, are presented.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
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Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility
Article Abstract:
The effects of Notch 1 signaling on development of male reproductive organs of transgenic mice are analyzed.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
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- Abstracts: Inhibition of Helicobacter pylori and associated urease by oregano and cranberry phytochemical synergies. Inhibition of Listeria monocytogenes in fish and meat systems by use of oregano and cranberry phytochemical synergies
- Abstracts: Navajo neurohepatopathy is caused by a mutation in the MPV17 gene. Leigh syndrome with nephropathy and Co[Q.sub.10] deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations
- Abstracts: Functional variants in the promoter region of chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia
- Abstracts: Xenopus Dead end mRNA is a localized maternal determinant that serves a conserved function in germ cell development
- Abstracts: Expression and regulation of the arsenic resistance operon of Acidiphilium multivorum AIU 301 plasmid pKW301 in Escherichia coli