Engineering increased stability in the antimicrobial peptide pediocin PA-1
Article Abstract:
Replacing the methionine-31 residue in the antimicrobial peptide pediocin PA-1 with Ala, Ile, or Leu keeps the peptide from losing activity at low temperatures without adversely affecting its antimicrobial activity. Pediocin PA-1 is used as a food preservative but it is inactivated at low temperatures.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Structure-function analysis of immunity proteins of pediocin-like bacteriocins: c-terminal parts of immunity proteins are involved in specific recognition of cognate bacteriocins
Article Abstract:
The immunity proteins of pediocon-like bacteriocins show a high degree of specificity with respect to the pediocin-like bacteriocin they recognize and confer immunity to. A study was conducted to identify regions of the immunity proteins that are involved in the specific recognition.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
New biologically active hybrid bacteriocins constructed by combining regions from various pediocin-like bacteriocins: the C-terminal region is important for determining specificity
Article Abstract:
Peptide synthesis leads to development of four new biologically active hybrid bacteriocins from different pediocin-like bacteriocins, and the C-terminal region is important for determining cell specificity. The response of the different bacterial strains to a hybrid bacteriocin is the same as the C-terminal derived bacteriocin, whereas it is different from the response of the N-terminal derived bacteriocin. The presence of contaminating proteases contributes to the instability of natural bacteriocins as compared to synthetic bacteriocins.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Synthesis of lactococcin 972, a bacteriocin produced by Lactococcus lactis IPLA 972, depends on the expression of a plasmid-encoded bicistronic operon
- Abstracts: Heterologous coproduction of enterocin A and pediocin PA-1 by Lactococcus lactis: detection by specific peptide-directed antibodies
- Abstracts: Novel signaling from the peripodial membrane is essential for eye disc patterning in Drosophila. Peripodial cells regulate proliferation and patterning of Drosophila imaginal discs
- Abstracts: Isolation of novel pelagic bacteria from the German Bight and their seasonal contributions to surface picoplankton
- Abstracts: Molecular, serological, and virulence characteristics of Vibrio parahaemolyticus isolated from environmental, food, and clinical sources in North America and Asia