New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis

Article Abstract:

A combination of strategies involving high-density pyrosequencing and insertional mutagenesis was used to explore the pathogenic content of Acinetobacter baumanni. The DNA sequencing approach allowed elucidating any sequence of microbe and when combined with genetic screen could identify many novel genes important for microbial pathogenesis.

Genetic aspects, Gram-negative bacteria, Bacterial genetics, Virulence (Microbiology)

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The activity of the Nodal antagonist cerl-2 in the mouse node is required for correct L/R body axis

Article Abstract:

The function of cerl-2 a novel Nodal antagonist, which displays a unique asymmetric expression on the right side of mouse node, is studied. Cerl-2 plays a key role in restricting the Nodal signaling pathway toward the left side of the mouse embryo by preventing its activity in the right side.

Mesoderm, Organogenesis

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Getting connected: Analysis and principles of biological networks

Article Abstract:

The complex molecular networks employed in the execution of several complex biological processes are examined. The analysis helps in understanding the mechanisms involved in the normal cellular processes and disease pathologies, as these networks are different from the random networks.

Physiological regulation, Biological control systems, Biological systems

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