New insights into the interaction of Ras with the plasma membrane
Article Abstract:
Studies have revealed that intracellular membranes and vesicular transport are significantly involved in the passage of Ras proteins to the inner surface of the plasma membrane. The farnesylation of the cysteine of the C-terminal CAAX motif is the first component that facilitate Ras protein localization to the plasma membrane. The second component is proteolytic removal of the AAX residues. Such process will lead to the carboxyl methylation of the C terminus.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Roles for proteolysis and trafficking in notch maturation and signal transduction
Article Abstract:
Experiments performed by various groups confirm the validity of the proteolysis model of Notch signaling as well as the roles of proteolysis and trafficking of Notch during receptor maturation. In these studies, two molecules that undergo similar patterns of proteolysis were examined. These included the beta-amyloid precursor protein and the sterol regulatory element binding protein.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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