Nonlinear ribosome migration on cauliflower mosaic virus 35S RNA
Article Abstract:
A study of ribosome migration on Cauliflower mosaic virus 35S RNA is presented. The Cauliflower mosaic virus contains a 600-nucleotide leader sequence and several open reading frames that by themselves should inhibit the translation of downstream coding regions. However, certain plant cells allow the translation of downstream regions depending on some properties of the leader sequence. Analyses of ribsome entry and the migration of potential scanning complexes on mRNAs showed that direct transfer, or shunting, of the scanning complex from an upstream shunt donor site to a downstream shunt acceptor site is possible without scanning the intervening region.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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The intracellular localization of messenger RNAs
Article Abstract:
Intracellular localization of mRNAs seems to occur in all cell types that exhibit polarity, probably for targeting proteins. Localization of mRNA is important as it allows for local regulation of the translational process. In case of isomers of protein, such a localization prevents formation of heteromultimers. mRNA localization may also be involved in generating polarity. The cis-acting sequences required for localization of mRNA are present in the 3'UTRs of the DNA transcript. Spatial control of mRNA stability, attachment to specific binding sites, vectorial nuclear export and active transport are the mechanisms involved in transport of mRNA.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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The pathway of HCV IRES-mediated translation initiation
Article Abstract:
A revised model of hepatitis C virus (HCV) internal ribosome entry site (IRES) translation initiation provides a context to understand the function of different HCV IRES domains during translation initiation. The HCV IRES directly regulates the assembly of translation initiation complexes on viral mRNA by a sequential pathway that is distinct from canonical eukaryotic initiation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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