Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA replication

Article Abstract:

Mouse models and human cancer-derived cells have shown that nuclear accumulation of catalytically active mutant cyclin D1/CDK4 complexes have triggered DNA rereplication, resulting from Cdt1 stabilization, which in turn has triggered the DNA damage checkpoints and p53-dependent apoptosis. The analysis has shown how uncoupling of critical cell cycle regulatory events will perturb DNA replication fidelity, thus contributing to neoplastic transformation.

DNA damage, Mutation (Biology), Mutation, Phosphoproteins, DNA replication

---

Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon

Article Abstract:

The effect of the loss of the mesenchymal transcription factor Foxl1, which results in an increase in the tumor multiplicity in the colon of Adenomatous Polyposis Coli (APC) mice is described. The studies show that Foxl1 is the first mesenchymal Modifier of Min and plays an important role in gastrointestinal tumorigenesis.

Genetic aspects, Carcinogenesis, Stomach cancer, Colon cancer

---

Similar abstracts:

• Abstracts: Evidence that mutations in the X-linked DDP gene cause incompletely penetrant and variable skewed X inactivation
• Abstracts: PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. Post-implantation mouse conceptuses produce paracrine signals that regulate the uterine endometrium undergoing decidualization
• Abstracts: Identification of a DNA methyltransferase gene carried on a pathogenicity island-like element (VPAI) in Vibrio parahaemolyticus and its prevalence among clinical and environmental isolates
• Abstracts: Isolation and characterization of Vibrio tubiashii outer membrane proteins and determination of a toxR homolog
• Abstracts: Race and sex differences and contribution of height: A study on bone size in healthy Caucasians and Chinese. Evidence for a major gene underlying bone size variation in the Chinese

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.