Nuclear export receptors: From importin to exportin
Article Abstract:
Nuclear import involves pore docking, NLS recognition, translocation through pore, and release from the side of the pore. Ran, the small GTPase, is needed for nuclear import. RNAs leave the nucleus through the nuclear pore, and work by the Hope and Cullen laboratories has delineated the critical features of a nuclear export signal (NES). In the search for an export receptor, a screening method has successfully identified mutations in known transport-related factors. It is believed that the exportin 1, the export receptor, recognizes an NES as an export signal.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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A small, stable RNA induced by oxidative stress: role as a pleiotropic regulator and antimutator
Article Abstract:
An exponential culture of Escherichia coli K12 cells were exposed in hydrogen peroxide to characterize the mechanisms that mediate the deletrious effects of reactive oxygen radicals in bacterial cells. Northern blot analysis of Escherichia coli cells that were exposed to hydrogen peroxide indicated the presence of a 109 nt RNA that was characterized as oxyS. The expression of the Escherichia coli gene was induced by oxidative stress and protected the cells from oxidative damage.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
User Contributions:
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