Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
Article Abstract:
SMRT, Sin3, and N-CoR establish protein-to-protein link between deacetylases and DNA-bound repressors hence, the term corepressors. These corepressors interact with each other and influence nuclear receptor to remodel chromatin structure without altering the regulatory complex through the help of hormone dependent adaptor HDAC. Transcriptional repression is achieved through regulation of chromatin structure resulting in an opposed cellular differentiation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein
Article Abstract:
Research demonstrates the role of inhibitor of acetyltransferases complex (INHAT) in blocking acetylation of histones by binding to histone and preventing access to acetyl transferase substrae. Data show that a multiprotein cellular complex inhibits the histone acetyltransferase activity of p300/CBP and PCAF.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock
Article Abstract:
Results reveal that the retinoid receptors interaction with circulating hormonal signals MOP4 and CLOCK causes retinoic acid phase shifts in Per2 mRNA and in the smooth muscle cells, leading to a nuclear receptor-mediated hormonal signaling for regulating a peripheral clock in the vasculature.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Accuracy and precision of methods to estimate the number of parents contributing to a half-sib progeny array. Genetic perspectives on the natural history of fish mating systems
- Abstracts: The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development
- Abstracts: Cloning and expression of the inositol monophosphatase gene from Methanococcus jannaschii and characterization of the enzyme
- Abstracts: Clathrin coats - threads laid bare. Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast
- Abstracts: Coupling between transcription termination and RNA polymerase inchworming. Isolation and characterization of sigma(sup)70 -retaining transcription elongation complexes from Escherichia coli