The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development
Article Abstract:
The Activin receptor ALK4 and the orphan receptor ALK7 have been found to mediate signaling by Nodal proteins in vertebrate development. Investigation was done using gain- and loss-of-function experiments in Xenopus embryos directly compared to ALK4. Biochemical and functional evidence suggests that the orphan type I serine-threonine kinase receptor ALK7 functions as a receptor for Xenopus Nodal-related 1 and mouse Nodal.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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Active repression of RAR signaling is required for head formation
Article Abstract:
Active repression of retinoic acid receptors (RAR) signaling has been found to be necessary for head formation. Specific reagents that reduce or augment RAR-mediated repression have been used to test the hypothesis that repression mediated through unliganded RARs might be important for anterior patterning.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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Synergistic interaction between Gdf1 and Nodal during anterior axis development
Article Abstract:
Combined genetic interaction between growth and differentiation factor 1 and nodal during the development of anterior axis is presented.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
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