Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation
Article Abstract:
Nucleolin and YB-1 are necessary for JNK-mediated interleukin-2 (IL-2) mRNA stabilization during T-cell activation. The mechanism for MRNA turnover has been studied using IL-2 mRNA as a model. The two major RNA proteins identified act through an NJK response element (JRE) in the 5' untranslated region (UTR). They specifically bind to the JRE and have a role for the JNK-signaling pathway.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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AU binding proteins recruit the exosome to degrade ARE-containing mRNAs
Article Abstract:
Research has been conducted on the inheritably unstable mammalian mRNA containing AU-rich elements. The mechanism of the rapid mRNA degradation dictated by the AU-rich elements has been investigated via the purification and characterization of the human exosome by mass spectrometry and the results are reported.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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Nucleoin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation
Article Abstract:
YB-1 and nucleolin are necessary for JNK-mediated interleukin-2 (IL-2) mRNA stabilization in T-cell activation. IL-2 mRNA was used as a model for describing the role for the NMK-signaling pathway in stabilizing IL2 mRNA in T-cell activation. Two major RNA-binding proteins were identified. They bind specifically to the JNK response element (JRE).
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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