Nucleosome positioning by the winged helix transcription factor HNF3

Article Abstract:

Nucleosome positioning is still under investigation. The mice transcriptional enhancer of the serum albumin gene acts in the liver. There regulatory factors occupy target sites on three particles designated N1, N2 and N3. They are nucleosome-like. Winged helix transcription factor HNF3 binds to two near-center sites in the N1 particle. Dinucleosome templates using the albumin enhancer sequence were created. Site-specific binding of HNF3 protein brought nucleosome positioning in vitro like that seen in liver nuclei. Binding of a transcription factor can put in place an underlying nucleosome core.

Research, Genetic regulation, Genetic transcription, Transcription (Genetics)

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Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin-remodelers in DNA double-strand break repair

Article Abstract:

The RSC and Swi/Snf ATP-dependent chromatin-remodeling complexes play key roles in double-strand break (DSB) repair, specifically by homologous recombination (HR). It is shown that Swi/Snf is required earlier, at or preceding the strand invasion step of HR, while RSC is required following synapsis for completion of the recombinational repair event.

Adenosine triphosphate, ATP

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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1

Article Abstract:

The role of Rad9-Hus1-Rad1 (9-1-1) proteins in activating cell cycle checkpoint to allow time for repair of damaged DNA is examined and studied in detail.

DNA damage

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