OPA1 controls apoptosis cristae remodeling independently from mitochondrial fusion
Article Abstract:
Study is presented to show that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, is found to protect from apoptosis by preventing cytochrome c release independently from mitochondrial fusion. The results have shown that OPA1 has genetically and molecularly distinct functions in mitochondrial fusion and in cristae remodeling during apoptosis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling
Article Abstract:
A genetic approach is used to investigate the function of presenilin-associated rhomboid-like (PARL) and its potential role in optic atrophia 1(OPA1) processing. The results have shown that [Parl.sup.-1-] mitochondria undergo faster apoptotic cristae remodeling and cytochrome c release, implicating regulated intramembrane proteolysis in controlling apoptosis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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OPA1 and PARL keep a lid on apoptosis
Article Abstract:
Study is presented to show that cristae remodeling during apoptosis, which leads to the release of cytochrome c, is regulated by a rhomboid intramembrane protease PARL and a dynamin-related protein OPA1. The results have suggested that the PARL-OPA1 duo is required for maintaining the tightly folded structure of the mitochodrial inner membrane.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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