Overexcited or inactive ion channels in muscle disease
Article Abstract:
Human hereditary muscle diseases that exhibit membrane excitation abnormalities arise due to mutations in voltage-sensitive ion channels on surface membranes. Muscle sodium channel disease arises from variation in the equilibrium between two gating modes of inactivation. Muscle chloride channel diseases result from mutations in the CIS-1 protein that forms a functional channel. The ability of a patient to conduct action potentials in muscle is changed only temporarily and reversibly by ion channel mutations. The mutations allow proper functioning of cells till other extra- or intracellular conditions alter the molecular pathology.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Neurotransmitter action: opening of ligand-gated ion channels
Article Abstract:
Ligand-gated ion channels are responsible for controlling the rapid action of neurotransmitters at the synapse which involve intracellular events such as those undelying synaptic plasticity and memory formation. An overview of ligand-gated ion channels and how they mediate ion transport is presented. In addition, the recent discoveries concerning ion selectivity and conductance properties are also presented. These include the identification and partial characterization of the pore-lining segment, the cloning of the glutamate receptors, and structure-activity relationships of receptors and neurotransmitters.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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The cadherin superfamily at the synapse: more members, more missions
Article Abstract:
The cadherin superfamily is a family of molecules responsible for cell to cell adhesion. A number of studies have investigated these molecules, particularly, the mechanisms by which members of its subfamilies function in the interneuronal synapses. Proteins of this superfamily are classified as either classic or nonclassic type. Of the two, it is the classic cadherin that is involved in long-term potentiation. The novel nonclassic cadherin-related neuronal receptor may play a role in building specific synaptic connections.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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